• facebook
  • twitter
  • youtube


[ 過去のニュースはこちら ]

2021 年11月30日
Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a.
Nakazawa Y, Nishiyama N, Koizumi H, Kanemaru K, Nakahashi-Oda C, Shibuya A.
eLife, 10:e61999, 2021
DNAM-1 versus TIGIT: competitive roles in tumor immunity and inflammatory responses.
Shibuya A, Shibuya K.
Int Immunol, 2021, in press
Science Immunologyに発表した論文がプレスリリースされました。
生命システム医学専攻4年中村(新谷)優歩さんの論文がInternational Immunologyにアクセプトされました。
DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-γ production.
Nakamura-Shinya Y, Iguchi-Manaka A, Murata R, Sato K, Van Vo A, Kanemaru K, Shibuya A, Shibuya K.  
Int Immunol, 2021, in press
生命システム医学専攻4年Mariana Almeidaさんと柴垣翔平研究員の論文がBBRC誌にアクセプトされました。
An inhibitory immunoreceptor, Allergin-1, suppresses FITC-induced type 2 contact hypersensitivity.
Almeida M, Shibagaki S, Tahara-Hanaoka S, Shibayama S, Shibuya A.  
BBRC, 579:146-152, 2021
小田ちぐさ助教の論文がScience Immunology誌にアクセプトされました。
CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke.
Nakahashi-Oda C, Fujiyama S, Nakazawa Y, Kanemaru K, Wang Y, Lyu W, Shichita T, Kitaura J, Abe F, Shibuya A.  
Sci Immunol, 6(64):eabe7915, 2021
本研究室とTNAX biopharma株式会社との共同研究成果プレスリリースされました。
Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
Iijima A, Kanemaru K, Wang Y, Nabekura T, Nakamura Y, Fujisawa Y, Mori D, Ohmuraya M, Yamasaki S, Tahara-Hanaoka S, Shibuya A.  
BBRC, 561:101-105, 2021


画像クリックで各研究内容へ移動 CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke. Nakahashi-Oda C et. al.
Science Immunology 2021
Abstract (PubMed)
画像クリックで各研究内容へ移動 DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions. Sato K et. al.
Proc Natl Acad Sci USA 2021
Abstract (PubMed)
画像クリックで各研究内容へ移動 Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells. Okumura G et. al.
J Exp Med 2020
Abstract (PubMed)
画像クリックで各研究内容へ移動 Type 1 innate lymphoid cells protect mice from acute liver injury via interferon-g secretion for upregulating Bcl-xL expression in hepatocytes. Nabekura T et. al.
Immunity 2020
Abstract (PubMed)
画像クリックで各研究内容へ移動 Clec10a regulates mite-induced dermatitis. Kanemaru K et. al.
Science Immunology 2019
Abstract (PubMed)
画像クリックで各研究内容へ移動 Autonomous regulation of IgE-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a. Wang Y et. al.
J Allergy and Clin Immunology 2019
Abstract (PubMed)
画像クリックで各研究内容へ移動 Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling. Honda S et. al.
Nature Communications 2016
Abstract (PubMed)
画像クリックで各研究内容へ移動 Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nakahashi-Oda C et. al.
Nature Immunology 2016
Abstract (PubMed)
画像クリックで各研究内容へ移動 Immune regulation by Fcα/μ receptor (CD351) on marginal zone B cells and follicular dendritic cells. Shibuya A et. al.
Immunological Reviews 2015
Abstract (PubMed)
画像クリックで各研究内容へ移動 Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. Totsuka N et. al.
Nature Communications 2014
Abstract (PubMed)
画像クリックで各研究内容へ移動 Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection. Nabekura T et. al.
Immunity 2014
Abstract (PubMed)
画像クリックで各研究内容へ移動 Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2. Kim Y et. al.
Cell Host & Microbe 2014
Abstract (PubMed)
画像クリックで各研究内容へ移動 Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. Nakahashi-Oda C et. al.
Journal of Experimental Medicine 2012
Abstract (PubMed)
画像クリックで各研究内容へ移動 The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
Nakano-Yokomizo T et. al.
Journal of Experimental Medicine 2011
Abstract (PubMed)
画像クリックで各研究内容へ移動 Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice.
Nabekura T et. al.
Proc Natl Acad Sci USA 2010
Abstract (PubMed)
画像クリックで各研究内容へ移動 An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Hitomi K et. al.
Nature Immunology 2010
Abstract (PubMed)
画像クリックで各研究内容へ移動 Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice. Honda S et. al.
Proc Natl Acad Sci USA 2009
Abstract (PubMed)
画像クリックで各研究内容へ移動 Accelerated tumor growth in mice deficient in DNAM-1 receptor. Iguchi-Manaka A et. al.
Journal of Experimental Medicine 2008
Abstract (PubMed)
画像クリックで各研究内容へ移動 Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor. Tahara-Hanaoka S et. al.
Blood 2006
Abstract (PubMed)
画像クリックで各研究内容へ移動 Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. Yotsumoto K et. al.
Journal of Experimental Medicine 2003
Abstract (PubMed)
画像クリックで各研究内容へ移動 CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. Shibuya K et. al.
Journal of Experimental Medicine 2003
Abstract (PubMed)
画像クリックで各研究内容へ移動 Fcα/μ receptor mediates endocytosis of IgM-coated microbes Shibuya A et. al.
Nature Immunology 2000
Abstract (PubMed)