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生命システム医学専攻4年Mariana Almeidaさんと柴垣翔平研究員の論文がBBRC誌にアクセプトされました。
An inhibitory immunoreceptor, Allergin-1, suppresses FITC-induced type 2 contact hypersensitivity.
Almeida M, Shibagaki S, Tahara-Hanaoka S, Shibayama S, Shibuya A.  
BBRC, in press
小田ちぐさ助教の論文がScience Immunology誌にアクセプトされました。
CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke
Nakahashi-Oda C, Fujiyama S, Nakazawa Y, Kanemaru K, Wang Y, Lyu W, Shichita T, Kitaura J, Abe F, Shibuya A.  
Sicence Immunol, in press
本研究室とTNAX biopharma株式会社との共同研究成果プレスリリースされました。
Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
Iijima A, Kanemaru K, Wang Y, Nabekura T, Nakamura Y, Fujisawa Y, Mori D, Ohmuraya M, Yamasaki S, Tahara-Hanaoka S, Shibuya A.  
BBRC, 561:101-105, 2021
DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions.
Sato K, Yamashita-Kanemaru Y, Abe F, Murata R, Nakamura-Shinya Y, Kanemaru K, Muratani M, Veillette A, Goto M, Ito M, Shibuya A, Shibuya K.
Proc Natl Acad Sci USA, 2021
渋谷和子准教授が令和2年度Best teacher's awardを受賞しました。今回で16年連続になります。
金丸由美さん筆頭論文がMonoclonal Antibodies in Immunodiagnosis and Immunotherapy誌にアクセプトされました。
Suppression of Th1 and Th17 proinflammatory cytokines and upregulation of Foxp3 expression by a humanized anti-DNAM-1 monoclonal antibody.
Yamashita-Kanemaru Y, Oh-oka K, Abe F, Shibuya K, Shibuya A.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 40(2):52-59, 2021


画像クリックで各研究内容へ移動 DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions. Sato K et. al.
Proc Natl Acad Sci USA 2021
Abstract (PubMed)
画像クリックで各研究内容へ移動 Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells. Okumura G et. al.
J Exp Med 2020
Abstract (PubMed)
画像クリックで各研究内容へ移動 Type 1 innate lymphoid cells protect mice from acute liver injury via interferon-g secretion for upregulating Bcl-xL expression in hepatocytes. Nabekura T et. al.
Immunity 2020
Abstract (PubMed)
画像クリックで各研究内容へ移動 Clec10a regulates mite-induced dermatitis. Kanemaru K et. al.
Science Immunology 2019
Abstract (PubMed)
画像クリックで各研究内容へ移動 Autonomous regulation of IgE-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a. Wang Y et. al.
J Allergy and Clin Immunology 2019
Abstract (PubMed)
画像クリックで各研究内容へ移動 Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling. Honda S et. al.
Nature Communications 2016
Abstract (PubMed)
画像クリックで各研究内容へ移動 Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nakahashi-Oda C et. al.
Nature Immunology 2016
Abstract (PubMed)
画像クリックで各研究内容へ移動 Immune regulation by Fcα/μ receptor (CD351) on marginal zone B cells and follicular dendritic cells. Shibuya A et. al.
Immunological Reviews 2015
Abstract (PubMed)
画像クリックで各研究内容へ移動 Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. Totsuka N et. al.
Nature Communications 2014
Abstract (PubMed)
画像クリックで各研究内容へ移動 Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection. Nabekura T et. al.
Immunity 2014
Abstract (PubMed)
画像クリックで各研究内容へ移動 Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2. Kim Y et. al.
Cell Host & Microbe 2014
Abstract (PubMed)
画像クリックで各研究内容へ移動 Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. Nakahashi-Oda C et. al.
Journal of Experimental Medicine 2012
Abstract (PubMed)
画像クリックで各研究内容へ移動 The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
Nakano-Yokomizo T et. al.
Journal of Experimental Medicine 2011
Abstract (PubMed)
画像クリックで各研究内容へ移動 Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice.
Nabekura T et. al.
Proc Natl Acad Sci USA 2010
Abstract (PubMed)
画像クリックで各研究内容へ移動 An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Hitomi K et. al.
Nature Immunology 2010
Abstract (PubMed)
画像クリックで各研究内容へ移動 Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice. Honda S et. al.
Proc Natl Acad Sci USA 2009
Abstract (PubMed)
画像クリックで各研究内容へ移動 Accelerated tumor growth in mice deficient in DNAM-1 receptor. Iguchi-Manaka A et. al.
Journal of Experimental Medicine 2008
Abstract (PubMed)
画像クリックで各研究内容へ移動 Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor. Tahara-Hanaoka S et. al.
Blood 2006
Abstract (PubMed)
画像クリックで各研究内容へ移動 Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. Yotsumoto K et. al.
Journal of Experimental Medicine 2003
Abstract (PubMed)
画像クリックで各研究内容へ移動 CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. Shibuya K et. al.
Journal of Experimental Medicine 2003
Abstract (PubMed)
画像クリックで各研究内容へ移動 Fcα/μ receptor mediates endocytosis of IgM-coated microbes Shibuya A et. al.
Nature Immunology 2000
Abstract (PubMed)