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A humanized monoclonal antibody against CD300A ameliorates acute ischemic stroke in humanized mice.
Abe F, Nakahashi-Oda C, Lee H, Bao TDD, Shibuya K, Shibuya A
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, in press
Inhibitory immunoreceptors CD300a and CD300lf cooperate to regulate mast cell activation.
Lee H, Nakahashi-Oda C, Lyu W, Tanaka M, Rai A, Muramoto Y, Wang Y, Mizuno S, Shibuya K, Shibuya A.
J Immunol, in press
Clec12b alleviates mite-induced dermatitis by regulating P2RX7-mediated mast cell activation in mice.
Iijima A, Matsuda K, Yamasaki S, Shibuya K, Shibuya A.
Allergy,28 November 2024 doi.org/10.1111/all.16401
CD25+FOXP3+CD45RA- regulatory T-cell infiltration as a prognostic biomarker for endometrial carcinoma.
Suto A, Minaguchi T, Qi N, Fujieda K, Itagaki H, Tenjimbayashi Y, Shikama A, Tasaka N, Akiyama A, Nakao S, Nakahashi-Oda C, Kobayashi Y, Shibuya A, Satoh T.
BMC Cancer. 2024 Sep 4;24(1):1100. doi: 10.1186/s12885-024-12851-0.
Concanavalin-A-Induced Acute Liver Injury in Mice.
Nabekura T, Matsuo S, Shibuya A.
Curr Protoc. 2024 Aug;4(8):e1117. doi: 10.1002/cpz1.1117.PMID: 39126326
THEMIS2 impairs anti-tumor activity of NK cells by suppressing activating NK receptor signaling
Deborah EA, Nabekura T, Shibuya K, Shibuya A
J Immunol, 2024 Jun 1;212(11):1819-1828. doi: 10.4049/jimmunol.2300771.
An inhibitory immunoreceptor Allergin-1 regulates the intestinal dysbiosis and barrier function in mice.
Lin Y-H, Tahara-Hanaoka S, Obana N, Fukuda S, Shibuya A.
Int Immunol,2024 Mar 5:dxae010. doi: 10.1093/intimm/dxae010.
Essential role of CD155 glycosylation in functional binding to DNAM-1 on natural killer cells.
Tahara S, Okumura G, Matsuo T, Shibuya A, Shibuya K.
Int Immunol, 2024 Apr 27;36(6):317-325. doi: 10.1093/intimm/dxae005.
Human basophils promote IgE-dependent oral allergen-induced anaphylaxis in humanized mice.
Lin Y-H, Tahara-Hanaoka S, Shibuya A.
Allergol Int,2023 Dec 1:S1323-8930(23)00119-3. doi: 10.1016/j.alit.2023.11.007.
Development of monoclonal antibodies specific to either CD300AR111 or CD300AQ111 or both.
Koizumi H, Nakahashi-Oda C, Lyu W, Yamashita-Kanemaru Y, Tabuchi K, Shibuya K, Shibuya A.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2023 Oct;42(5):182-185. doi: 10.1089/mab.2023.0017.
Themis2 regulates natural killer cell memory function and formation.
Nabekura T, Deborah EA, Tahara S, Arai Y, Love PE, Kako K, Fukamizu A, Muratani M, Shibuya A.
Nat Commun,14, 7200 (2023).doi:org/10.1038/s41467-023-42578-8
Annexin A5 inhibits mast cell activation via Allergin-1 immunoreceptor.
Almeida MS., Tahara-Hanaoka S., Shibagaki S., Niizuma K., Hitomi K., Shinkai Y., Shibayama S., Shibuya A.
Allergy, 11 August 2023 doi: 10.1111/all.15851
DNAM-1 immunoreceptor protects mice from concanavalin A-induced acute liver injury by reducing neutrophil infiltration.
Matsuo S, Nabekura T, Matsuda K, Shibuya K, Shibuya A.
J Immunology ,211 (6): 954–963,2023 doi:10.4049/jimmunol.2200705
Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches.
Asahi T, Abe S, Cui G, Shimba A, Nabekura T, Miyachi H, Kitano S, Ohira K, Dijkstra JM, Miyazaki M, Shibuya A, Ohno H, Ikuta K.
Elife. 2023 Jun 22;12:e84209. doi: 10.7554/eLife.84209.
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy
Yamada T, Tatematsu M, Takasuga S, Fuchimukai A, Yamagata K, Seki S, Kuba K, Yoshida H, Taniuchi I, Bernhardt G, Shibuya K, Shibuya A, Yamada T, Ebihara T.
J Exp Med (2023) 220 (7): e20222005. doi:10.1084/jem.20222005
Differential isoform expression of Allergin-1 during acute and chronic inflammation.
Geerdink RJ, Pascoal Ramos MI, van den Hoogen LL, Radstake TRDJ, Shibayama S, Shibuya A, Bont L, Meyaard L.
Inflamm Dis. 2022 Dec;10(12):e739. doi: 10.1002/iid3.739.
Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes.
Miyashita D, Inoue R, Tsuno T, Okuyama T, Kyohara M, Nakahashi-Oda C, Nishiyama K, Fukushima S, Inada Y, Togashi Y, Shibuya A, Terauchi Y, Shirakawa J.
iScience 25(12) 105662, 2022.
G307S DNAM-1 Mutation Exacerbates Autoimmune Encephalomyelitis via Enhancing CD4+ T Cell Activation.
Murata R, Kinoshita S, Matsuda K, Kawaguchi A, Shibuya A, Shibuya K.
J Immunol (2022) 209 (12): 2304–2312.
CD96 Blockade Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis via Suppression of IL-17A Production by Dermal γδ T Cells.
Oh-oka K, Abe F, Shibuya A, Shibuya K.
J Immunol (2022) 209 (12): 2313–2321.
The CD16 and CD32b Fc-gamma receptors regulate antibody-mediated responses in mouse natural killer cells.
Aguilar O, Gonzalez-Hinojosa M, Arakawa-Hoyt J, Millan A, Gotthardt D, Nabekura T, Lanier LL.
J Leuk Biol, Volume 113, Issue 1, January 2023, Pages 27–40
Interferon-β promotes the survival and function of induced regulatory T cells.
Nishiyama N, Nakahashi-Oda C, Shibuya A.
Cytokine, 158, October 2022, 156009
CD155 mutation (Ala67Thr) increases the binding affinity for and the signaling via an inhibitory immunoreceptor TIGIT.
Matsuo T, Iguchi-Manaka A, Shibuya A, Shibuya K.
Cancer Sci, 113(11):4001-4004, 2022 doi:10.1111/cas.15526
The secretome of irradiated peripheral blood mononuclear cells attenuates activation of mast cells and basophils.
Laggner M, Acosta GS, Kitzmüller C, Copic D, Gruber F, Altenburger LM, Vorstandlechner V, Gugerell A, Direder M, Klas K, Bormann D, Peterbauer A, Shibuya A, Bohle B, Ankersmit HJ, Mildner M.
EBioMedicine. 2022 Jun 4;81:104093. doi: 10.1016/j.ebiom.2022.104093.
Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming.
Aizawa S, Nishimura K, Mondejar GS, Kumar A, Bui PL, Tran YTH, Kuno A, Muratani M, Kobayashi S, Nabekura T, Shibuya A, Sugihara E, Sato T, Fukuda A, Hayashi Y, Hisatake K.
Stem Cell Rep, 17 (1):53-67, 2022
Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a.
Nakazawa Y, Nishiyama N, Koizumi H, Kanemaru K, Nakahashi-Oda C, Shibuya A.
eLife, 10:e61999, 2021
DNAM-1 versus TIGIT: competitive roles in tumor immunity and inflammatory responses.
Shibuya A, Shibuya K.
Int Immunol, 33(12)687-692, 2021
DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-γ production.
Nakamura-Shinya Y, Iguchi-Manaka A, Murata R, Sato K, Van Vo A, Kanemaru K, Shibuya A, Shibuya K.
Int Immunol, dxab099, 2021
CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke.
Nakahashi-Oda C, Fujiyama S, Nakazawa Y, Kanemaru K, Wang Y, Lyu W, Shichita T, Kitaura J, Abe F, Shibuya A.
Sci Immunol, 6(64):eabe7915, 2021
An inhibitory immunoreceptor, Allergin-1, suppresses FITC-induced type 2 contact hypersensitivity.
Almeida M, Shibagaki S, Tahara-Hanaoka S, Shibayama S, Shibuya A.
BBRC, 579:146-152, 2021
Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
Iijima A, Kanemaru K, Wang Y, Nabekura T, Nakamura Y, Fujisawa Y, Mori D, Ohmuraya M, Yamasaki S, Tahara-Hanaoka S, Shibuya A.
BBRC, 561:101-105, 2021
DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions.
Sato K, Yamashita-Kanemaru Y, Abe F, Murata R, Nakamura-Shinya Y, Kanemaru K, Muratani M, Veillette A, Goto M, Ito M, Shibuya A, Shibuya K.
Proc Natl Acad Sci USA, 2021
Suppression of Th1 and Th17 proinflammatory cytokines and upregulation of Foxp3 expression by a humanized anti-DNAM-1 monoclonal antibody.
Yamashita-Kanemaru Y, Oh-oka K, Abe F, Shibuya K, Shibuya A.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 40(2):52-59, 2021
ILC1: Guardians of the oral mucosa against enemy viruses.
Nabekura T, Shibuya A.
Immunity, 54(2):196-198, 2021
Type 1 innate lymphoid cells: Soldiers at the front line of immunity.
Nabekura T, Shibuya A.
Biomedical Journal, 44(2):115-122, 2021
HVJ-E containing PD-L1 siRNA inhibits immunosuppressive activities and elicits antitumor immune responses in glioma.
Sugii N, Matsuda M, Okumura G, Shibuya A, Ishikawa E, Kaneda Y, Matsumura A.
Cancer Science, 112(1):81-90, 2021
Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells.
Nishimura T, Xu H, Iwasaki M, Karigane D, Saavedra B, Takahashi Y, Suchy FP, Monobe S, Martin RM, Ohtaka M, Nakanishi M, Burrows SR, Cleary ML, Majeti R, Shibuya A, Nakauchi H.
Gene Ther, 27(10-11):525-534, 2020
MAIR‐II deficiency ameliorates cardiac remodelling post‐myocardial infarction by suppressing TLR9‐mediated macrophage activation.
Yonebayashi S, Tajiri K, Murakoshi N, Xu D, Li S, Feng D, Okabe Y, Yuan Z, Song Z, Aonuma K, Shibuya A, Aonuma K, Ieda M.
J Cell Mol Med, 24(24):14481-14490, 2020
Expression and function of DNAM-1 on human B-lineage cells.
Nagayama-Hasegawa Y, Honda S, Shibuya A, Shibuya K.
Clinical Cytometry, 98(4):368-374, 2020
Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice.
Lin YH, Tahara-Hanaoka S, Nagai K, Yoshikawa S, Kubo M, Shibayama S, Karasuyama H, Shibuya A.
International Immunology, 32(3):213-219, 2020
Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells.
Okumura G, Iguchi-Manaka A,Murata R,Yamashita-Kanemaru Y, Shibuya A, Shibuya K.
J Exp Med, 217(4):e20191290, 2020
A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease.
Goshima Y, Nakaoka S, Ohashi K, Sakamaki H, Shibuya K, Shibuya A.
PLOS ONE, 15(2):e0228508, 2020
Allergin-1 immunoreceptor suppresses house dust mite-induced allergic airway inflammation.
Miki H, Tahara-Hanaoka S, Almeida MS, Hitomi K, Shibagaki S, Kanemaru K, Lin YH, Iwata K, Miyake S, Shibayama S, Sumida T, Shibuya K, Shibuya A.
Journal of Immunology, 204(4):753-762, 2020
Type 1 innate lymphoid cells protect mice from acute liver injury via interferon-g secretion for upregulating Bcl-xL expression in hepatocytes.
Nabekura T, Riggan L, Hildreth AD, O'Sullivan TE, Shibuya A.
Immunity, 52(1):96-108.e9, 2020
High expression of soluble CD155 in estrogen receptor-negative breast cancer.
Iguchi-Manaka A, Okumura G, Ichioka E, Kiyomatsu H, Ikeda T, Bando H, Shibuya A, Shibuya K.
Breast Cancer, 27(1):92-99, 2020
Cutting Edge: Involvement of the immunoreceptor CD300c2 on alveolar macrophages in bleomycin-induced lung fibrosis.
Nakazawa Y, Ohtsuka S, Nakahashi-Oda C, Shibuya A.
Journal of Immunology, 203(12):3107-3111, 2019
Clec10a regulates mite-induced dermatitis.
Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A.
Science Immunology, 4(42)6908, 2019
Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation.
Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M.
Immunity, 51(3):508-521, 2019
Autonomous regulation of IgE-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a.
Wang Y, Nakahashi-Oda C, Okayama Y, Shibuya A.
J Allergy Clin Immun, 144(1):323-327, 2019
The cis-regulatory atlas of the mouse immune system
Hideyuki Yoshida, Caleb A. Lareau, Ricardo N. Ramirez, Samuel A. Rose, Barbara Maier, Aleksandra Wroblewska, Fiona Desland, Aleksey Chudnovskiy, Arthur Mortha, Claudia Dominguez, Julie Tellier, Edy Kim, Dan Dwyer, Susan Shinton, Tsukasa Nabekura, YiLin Qi, Bingfei Yu, Michelle Robinette, Ki-Wook Kim, Amy Wagers, Andrew Rhoads, Stephen L. Nutt, Brian D. Brown, Sara Mostafavi, Jason D. Buenrostro, Christophe Benoist, and the Immunological Genome Project
Cell, 176(4):897-912, 2018
Identification and isolation of splenic tissue resident macrophage subpopulations by flow cytometry.
Fujiyama S, Nakahashi-Oda C, Abe F, Wang Y, Sato K, Shibuya A
Int Immunol, 31(1):51-56, 2018
Allergy inhibitory receptor-1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages.
Iizuka A, Segawa S, Kondo Y, Kaneko S, Yokosawa M, Furuyama K, Miki H, Tahara-Hanaoka S, Shibuya A, Tsuboi H, Goto D, Matsumoto I, Shibayama S, Sumida T.
Int J Rheum Dis, 21(12):2071-2078, 2018
Exploring the Gut Fungi-Lung Allergy Axis.
Shibuya A & Shibuya K.
Cell Host Microbe, 24(6):755-757, 2018
Elovl6 regulates mechanical damage–induced keratinocyte death and skin inflammation.
Nakamura Y, Matsuzaka T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A.
Cell Death and Diseases, 9(12):1181, 2018
Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.
Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima YI, Yanagisawa M, Funato H, Hoshino M.
Cell Rep. 24(1):79-94, 2018
Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties.
Chen C, Okita Y, Watanabe Y, Abe F, Fikry MA, Ichikawa Y, Suzuki H, Shibuya A, Kato M.
Cancer Res, 78(22):6424-6435, 2018
Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation.
Takenaka E., Vo A, Yamashita-Kanemaru Y, Shibuya A, Shibuya K.
Sci. Rep. 8(1):15180, 2018
Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice.
Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A.
Int Immunol, 30(9):429-434, 2018
Cutting Edge: Identification of Marginal Reticular Cells as Phagocytes of Apoptotic B Cells in Germinal Centers.
Sato K, Honda S, Shibuya A, Shibuya K.
J Immunol, 200(11):3691-3696, 2018
TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT.
Nakamura Y, Naito K, Yamashita-Kanemaru Y, Komori D, Hirochika R, Shibuya A, Shibuya K.
Monoclon Antib Immunodiagn Immunother, 37(2):105-109, 2018
Crk adaptor proteins regulate NK cell expansion and differentiation during mouse cytomegalovirus infection.
Nabekura T, Chen Z, Schroeder C, Park T, Vivier E, Lanier LL, Liu D.
J Immunol, 200(10):3420-3428, 2018
A pro-inflammatory role of Fcα/μR on marginal zone B cells in sepsis.
Shibuya A, Honda SI, Shibuya K.
Int Immunol, 29(11):519-524, 2017
Cutting Edge: NKG2D signaling enhances Ly49H+ natural killer cell responses but alone is insufficient to drive expansion during mouse cytomegalovirus infection.
Nabekura T, Gotthardt D, Niizuma K, Trsan T, Jenus T, Jonjic S, Lanier LL.
J Immunol, 199(5):1567-1571, 2017.
Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient Kitw-sh/w-sh mice.
Shibagaki S,Tahara-Hanaoka S, Hiroyama T, Nakamura Y, Shibuya A.
Int Immunol, 29(5): 235-242,2017
Development and characterization of novel monoclonal antibodies against human DNAM-1.
Okumura G, Abe F, Hirochika R, Shibuya A., Shibuya K.
Monoclon Antib Immunodiagn Immunother,36(3):135-139,2017
Immunoreceptor CD300a on mast cells and dendritic cells regulates neutrophil recruitment in a murine model of sepsis.
Udayanga K G S, Nakamura Y, Nakahashi-Oda C, Shibuya A.
Int Immunol, 28(12):611-615, 2016
Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis.
Tsurusaki S, Tahara-Hanaoka S, Shibagaki S, Miyake S, Imai M, Shibayama S, Kubo M, Shibuya A.
Int Immunol, 28(12):605–609, 2016
Tracking the fate of antigen-specific versus cytokine-activated Natural Killer cells after cytomegalovirus infection.
Nabekura T, Lanier LL
J Exp Med, 213(12):2745-2758, 2016
Improved protocol for the isolation of naïve follicular dendritic cells.
Sato K, Honda SI, Shibuya A, Shibuya K.
Mol Immunol, 78:140-145, 2016
Activating receptors for self-MHC class I enhance effector functions and memory differentiation of natural killer cells during mouse cytomegalovirus infection.
Nabekura T, Lanier LL
Immunity, 45:74-82, 2016
Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL-10-induced modulation of phagocyte antifungal activity.
Haraguchi N, Kikuchi N, Morishima Y, Matsuyama M, Sakurai H, Shibuya A, Shibuya K, Taniguchi M, Ishii Y.
Eur J Immunol, 46(7):1691-1703, 2016
Soluble DNAM-1, as a predictive biomarker for acute graft-versus-host disease.
Kanaya M, Shibuya K, Hirochika R, Kanemoto M, Ohashi K, Okada M, Wagatsuma Y, Cho Y, Kojima H, Teshima T, Imamura M, Sakamaki H, Shibuya A.
PLoS One, 11(6) :e0154173, 2016
Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling.
Honda S, Sato K, Totsuka N, Fujiyama S, Fujimoto M, Miyake K, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A.
Nat Commun, 7:11498, 2016
Increased soluble CD155 in the serum of cancer patients.
Iguchi-Manaka A, Okumura G, Kojima H, Cho Y, Hirochika R, Bando H, Sato T, Yoshikawa H, Hara H, Shibuya A, Shibuya K.
PLoS One, 11(4):e0152982, 2016
Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces.
Nakahashi-Oda C, Udayanga KGS, Nakamura Y, Nakazawa Y, Miki H, Iino S, Tahara-Hanaoka S, Shibuya K, Shibuya A.
Nat Immunol, 17(4):441-450, 2016
CD155/CD226-interaction impacts on the generation of innate CD8+ thymocytes by regulating iNKT-cell differentiation.
Georgiev H, Ravens I, Shibuya A, F.ANvrster R, Bernhardt G.
Eur J Immunol, 46(4):993-1003, 2016
Expression of DNAM-1 (CD226) on inflammatory monocytes.
Vo.A.V., Takenaka E, Shibuya A, Shibuya K.
Mol Immunol, 69:70-76, 2016
Inhibitory Immunoreceptors on Mast Cells in Allergy and Inflammation.
Shibuya A, Nakahashi-Oda C, Tahara-Hanaoka S.
In: Nakao K, Minato N, Uemoto S, editors.
Innovative Medicine: Basic Research and Development [Internet]. Tokyo: Springer; 2015.
Tie2 signaling enhances mast cell progenitor adhesion to vascular cell adhesion molecule-1 (VCAM-1) through α4β1 integrin.
Kanemaru K, Noguchi E, Tokunaga T, Nagai K, Hiroyama T, Nakamura Y, Tahara-Hanaoka S, Shibuya A.
PLoS One, 10(12):e0144436, 2015
IgM-dependent phagocytosis in microglia is mediated by complement receptor 3, not Fcα/μ receptor.
Weinstein JR, Quan Y, Hanson JF, Colonna L, Iorga M, Honda S, Shibuya K, Shibuya A, Elkon KB, M.ANvller T.
J Immunol, 2015 Dec 1;195(11):5309-5317, 2015
Immune regulation by Fcα/μ receptor (CD351) on marginal zone B cells and follicular dendritic cells.
Shibuya A, Honda S.
Immunol Rev, 268(1):288-295, 2015
Identification and characterization of CD300H, a new member of the human CD300 immunoreceptor family.
Niizuma K, Tahara-Hanaoka S, Noguchi E, Shibuya A.
J Biol Chem, 290(36):22298-22308, 2015
CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
Yamashita-Kanemaru Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K.
J Immunol, 194(12):5644-5653, 2015
IL-33 receptor ST2 amplifies the expansion of natural killer cells and enhances host defense during mouse cytomegalovirus infection.
Nabekura T, Girard J, Lanier L L.
J Immunol, 194(12):5948-5952, 2015
Involvement of CD300a phosphatidylserine immunoreceptor in aluminum salt Adjuvant-induced Th2 responses.
Miki H, Nakahashi-Oda C, Sumida T, Shibuya A.
J Immunology, 194(11):5069-5076, 2015
Increased CD11b+ Gr-1+ cell population in the placenta after infection with Toxoplasma gondii.
Takeshima K, Sato K, Nabekura T, Nagamune K, Hamada H, Yoshikawa H, Shibuya A, Shibuya K.
Microbiol Immunol, 59: 95-98, 2015
Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background.
Kurita N, Honda S, Shibuya A.
Mol Immunol, 63(2): 367-372, 2015
Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice.
Nagumo Y, Iguchi-Manaka A, Shibuya A, Shibuya K.
PLoS One, 9(11):e112415, 2014
Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation.
Nabekura T, Lanier LL.
J Exp Med, 211(12):2455-65, 2014
Influence of MILR1 promoter polymorphism on expression levels and the phenotype of atopy.
Nanatsue K, Ninomiya T, Tsuchiya M, Tahara-Hanaoka S, Shibuya A, Masuko H, Sakamoto T, Hizawa N, Arinami T, Noguchi E.
J Hum Genet, 59(9)480-483, 2014
Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a.
Sabato V, Boita M, Shubber S, Bridts CH, Shibuya A, De Clerck LS, Falcone FH, Ebo DG.
J Allergy Clin Immunol, 134:734-737, 2014
Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration.
Totsuka N, Kim Y, Kanemaru K, Niizuma K, Umemoto E, Nagai K, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Miyasaka M, Shibuya K, Shibuya A.
Nat Commun, 5:4710, 2014
PPARβ/δ activation of CD300a controls intestinal immunity.
Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Johan A, Frank J G, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.
Scientific Reports, 4:5412, 2014
Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.
Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y.
BMC Nephrol, 15:89, 2014
Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.
Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier LL.
Immunity, 40(2): 225–234, 2014
TIGIT versus CD226: Hegemony or coexistence?
Georgiev H, Danisch S, Chambers BJ, Shibuya A, Förster R, Bernhardt G.
Eur J Immunol, 44:307-308, 2014
Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2.
Kim Y, Udayanga K G S, Totsuka N, Weinberg J B, Núñez G, Shibuya A.
Cell Host Microbe, 15,(1): 95–102, 2014
Involvement of Fcα/μR (CD351) in autoantibody production.
Yoshizawa Y, Honda S, Shibuya A.
Mol Immunol, 57(2):216-219, 2013
Expression and function of Allergin-1 on human primary mast cells.
Nagai Kei, Tahara-Hanaoka S, Morishima Y, Tokunaga T, Imoto Y, Noguchi,E, Kanemaru K, Imai M, Shibayama S, Hizawa N, Fujieda S, Yamagata K, Shibuya A.
PLoS One, 8(10):e76160, 2013
Molecular characterization of the dimer formation of Fcα/μ receptor (CD351).
Takagaki K, Satoh K, Honda S, Shibuya A.
Mol Immunol, 56(1-2):23-27, 2013
Natural killer cells: walking three paths down memory lane.
Min-Oo G, Kamimura Y, Hendricks DW, Nabekura T, Lanier LL.
Trends Immunol, 34(6):251-8, 2013.
Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells.
Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura K, Ohara O, Shibuya A, Wakeland E K, Li Q-Z, Miyazaki T.
Cell Reports, 3(4):1187-1198, 2013
Establishment and characterization of a novel Anti-DNAM-1 monoclonal antibody.
Yamashita Y, Abe F, Hirochika R, Tahara-Hanaoka S, Shibuya A, Shibuya K.
Monoclonal Antib Immunodiag Immunother, 32(1):60-64, 2013
CD226 interaction with CD155 impacts on retention and negative selection of CD8 positive thymocytes as well as T cell differentiation to follicular helper cells in Peyer's Patches.
Danisch S, Qiu Q, Seth S, Ravens I, Dorsch M, Shibuya A, Shibuya K, Förster R, Bernhardt G.
Immunobiology, 218(2):152-158, 2013
Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice.
Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S.
Eur J Immunol, 42(8):1999-2009, 2012
Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.
Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A.
J Exp Med, 209(8):1493-1503, 2012
Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor.
Nakahashi-Oda C, Tahara-Hanaoka S, Honda S, Shibuya K, Shibuya A.
Biochem Biophys Res Commun, 417:646-650, 2012
Isolation and characterization of naïve follicular dendritic cells.
Usui K, Honda S, Yoshizawa Y, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A.
Mol Immunol, 50:172-6, 2012.
B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fc.FNa/Nl receptor and in the absence of host cell contact.
Colombo MJ, Abraham D, Shibuya A, Alugupalli KR.
Immunol Res, 51:249-56, 2011
The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Nadia K. Tchao, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lewis L. Lanier, Shibuya A.
J Exp Med, 1;208(8):1661-1671, 2011
Ingested allergens must be absorbed systemically to induce systemic anaphylaxis. Ingested allergens must be absorbed systemically to induce systemic anaphylaxis.
Strait RT, Mahler A, Hogan S, Khodoun M, Shibuya A, Finkelman FD.
J Allergy Clin Immunol, 127:982-989, 2011
Reply to Seth et al.: DNAX accessory molecule-1 (DNAM-1) plays an important role in alloreactive CD8+ T cells responsible for the exacerbation of acute graft-versus-host disease.
Nabekura T, Shibuya K, Shibuya A.
Proc Natl Acad Sci USA, 108(10)E34, 2011.
Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice.
Nabekura T, Shibuya K, Takenaka E, Kai H, Shibata K, Yamashita Y, Harada K, Tahara-Hanaoka S, Honda S, Shibuya A.
Proc Natl Acad Sci USA, 107:18593-18598, 2010.
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.
Hitomi K, Tahara-Hanaoka S, Someya S, Fujiki A, Tada H, Sugiyama T, Shibayama S, Shibuya K, Shibuya A.
Nat Immunol, 11:601-607, 2010.
Requirement of the cytoplasmic portion for dimer formation of Fcα/μreceptor expressed on cell surface
Cho Y, Honda S, Yoshizawa Y, Takagaki K, Usui K, Shibuya A.
Mol. Immunol, 47:878-882, 2010.
Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice.
Honda S, Miyamoto A, Cho Y, Usui K, Kurita N, Takeshita K, Takahashi S, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A.
Proc Natl Acad Sci USA, 106:11230-11235, 2009.
Regulation of immune responses by the activating and inhibitory myeloid-associate immunoglobuline-like receptors (MAIR) (CD300).
Shibuya A, Nakahashi-Oda C, Tahara-Hanaoka S.
Immune Network, 9:41-45, 2009.
Identification of the Fca/mR isoform specifically expressed in the kidney tubule.
Kurita N, Honda S, Usui K, Shimizu Y, Miyamoto A, Tahara-Hanaoka S, Shibuya K,Shibuya A.
Mol Immunol, 46:749-753, 2009.
Receptor-mediated recognition of melanoma by NK cells and its implications for NK cell-based immunotherapy.
Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Höglund P, Kato K, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Kärre K, Shibuya A, Carbone E, Colucci F.
Tissue Antigen, 73:519-520, 2009.
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.
Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Höglund P, Kato K, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Kärre K, Shibuya S, Carbone E, Colucci F.
J Clin Invest, 119:1251-63, 2009.
Accelerated tumor growth in mice deficient in DNAM-1 receptor.
Iguchi-Manaka A, Kai H, Yamashita Y, Shibata K, Tahara-Hanaoka S, Honda S, Yasui Y, Kikutani H, Shibuya K, Shibuya A.
J Exp Med, 205, 2959-2964, 2008.
Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV.
Nakano T, Tahara-Hanaoka S, Nakahashi C, Can I, Totsuka N, Honda S-I, Shibuya K, Shibuya A.
Mol Immunol, 45:289-294, 2008.
Caspase-independent cell death by CD300LF (MAIR-V), an inhibitory immunoglobulin-like receptor on myeloid cells.
Can I, Tahara-Hanaoka S, Hitomi K, Nakano T, Nakahashi-Oda C, Kurita N, Honda S, Shibuya K, Shibuya A.
J Immunol, 180: 207-213, 2008.
Expression of a Splicing Isoform of MAIR-V (CD300LF), an inhibitory immunoglobulin-like receptor on myeloid cells.
Can I, Tahara-Hanaoka S, Shibuya A.
Hybridoma, 27:59-61, 2008.
LFA-1 decreases the antigen dose for T cell activation in vivo.
Wang Y, Shibuya K, Yamashita Y, Shirakawa J, Shibata K, Kai H, Yokosuka T, Saito T, Honda S, Tahara-Hanaoka S, Shibuya A.
Int Immunol, 20:1119-27, 2008.
Unusual biochemical features and follicular dendritic cell expression of human Fcalpha/mu receptor.
Kikuno K, Kang DW, Tahara K, Torii I, Kubagawa HM, Ho KJ, Baudino L,
Nishizaki N, Shibuya A, Kubagawa H
Eur J Immunol, 37:3540-3550, 2007
The adaptor protein CARD9 is essential for the activation of myeloid
cells through ITAM-associated and Toll-like receptors.
Hara H, Ishihara C, Takeuchi A, Imanishi T, Xue L, Morris SW, Inui M,
Takai T, Shibuya A, Saijo S, Iwakura Y, Ohno N, Koseki H, Yoshida H,
Penninger JM, Saito T.
Nat Immunol, 8, 619-629, 2007
Dual assemblies of an activating immune receptor, MAIR-II, with
ITAM-bearing adapters DAP12 and FcR chain on peritoneal macrophages.
Nakahashi C, Tahara-Hanaoka S, Totsuka N, Okoshi Y, Takai T, Ohkochi N,
Honda S-I, Shibuya K, Shibuya A.
J Immunol, 15;178(2):765-70. 2007
A critical role of LFA-1 in the development of Th17 cells and
induction of experimental autoimmune encephalomyelitis.
Wang Y, Kai, H, Chang F, Shibata K, Tahara-Hanaoka S, Honda S-I,
Shibuya A, Shibuya K.
Biochem Biophys Res Commun, 23;353(4):857-62. 2007
Th1 and Type 1 Cytotoxic T Cells Dominate the Responses in Tbet
Over- expression Transgenic Mice that Develop Contact Dermatitis.
Ishizaki K, Yamada A, Yoh K, Nakano T, Shimohata H, Maeda A, Fujioka Y,
Morito N, Kawachi Y, Shibuya K, Otsuka F, Shibuya A, Takahashi S.
J Immunol, 2007 Jan 1; 178(1):605-12.
Molecular and functional characteristics of the Fcα/μR,
a novel Fc receptor for IgM and IgA.
Shibuya A, Honda S.
Seminar in Immunohistopathol, 28：377-382、2006
Molecular characteristics of IgA and IgM Fc binding to the Fcalpha/muR.
Cho Y, Usui K, Honda S, Tahara-Hanaoka S, Shibuya K, Shibuya A.
Biochem Biophys Res Commun, Jun 23;345(1):474-8, 2006
A carbohydrate binding protein Galectin-1, promotes proliferation
of adult neural stem cells.
Sakaguchi M, Shingo T, Shimazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H,
Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H,
Sawamoto K, and Okano H.
Proc Natl Acad Sci USA, May 2;103(18):7112-7, 2006
LFA-1-dependent lipid rafts recruitment of DNAM-1 (CD226)
in CD4+ T cell.
Shirakawa J, Wang Y, Tahara-Hanaoka S, Honda S,Shibuya K and Shibuya A.
Int Immunol, 18(6):951-7, 2006
Critical role of M. tuberculosis for dendritic cell maturation to
induce collagen-induced arthritis in H-2b background of C57BL/6 mice.
Kai H, Shibuya K, Wang Y, Kameta H, Kameyama T, Tahara-Hanaoka S,
Miyamoto A, Honda S, Matsumoto I, Koyama A, Sumida T and Shibuya A.
Immunology, 118, 233-239, 2006
A specific CpG demethylation in the human IL-2 gene promoter as
an epigenetic memory.
Murayama A, Sakura K, Nakayama M, Yasuzawa K, Fujita E, Wang Y,
Ushijima T, Shibuya K, Shibuya A, Kawabe Y, Yanagisawa J.
EMBO J, 25:1081-92, 2006
Comment on"CD226 Is Specifically Expressed on the Surface of
Th1 Cells and Regulates Their Expansion and Effector Functions".
Shibuya K, Shibata K, Tahara-Hanaoka S and Shibuya A.
J Immunol, 176:3855, 2006
Tumor rejection by the poliovirus receptor family ligands of the
DNAM-1 (CD226) receptor.
Tahara-Hanaoka S, Shibuya K, Kai H, Miyamoto A, Morikawa Y, Ohkochi N,
Honda SI, Shibuya A
Blood, 107:1491-1496, 2006
Identification and characterization of murine DNAM-1 (CD226) and its
poliovirus receptor family ligands.
Tahara-Hanaoka, S., Miyamoto, A., Hara, A., Honda, S., Shibuya, K.
and Shibuya, A.,
Biochem Biophys Res Commun, 329, 996-1000, 2005.
Requirement of the serine at residue 329 for lipid raft recruitment
of DNAM-1 (CD226).
Shirakawa, J., Shibuya, K. and Shibuya, A.,
Int Immunol, 17, 217-23, 2005.
DNAM-1(CD226), a two-sword fencer for innate and adaptive immunity.
Shibuya, A., Tahara-Hanaoka, S. and Shibuya, K.,
Curr Med Chem-AIAA, 4, 53-58, 2005.
Requirement of the tyrosines at residues 258 and 270 of MAIR-I in
inhibitory effect on degranulation from basophilic leukemia RBL-2H3.
Okoshi, Y., Tahara-Hanaoka, S., Nakahashi, C., Honda, S., Miyamoto, A., Kojima,
H., Nagasawa, T., Shibuya, K. and Shibuya, A.,
Int Immunol, 17, 65-72, 2005.
Positional identification of an asthma susceptibility gene on human
chromosome 5q33.
Noguchi, E., Yokouchi, Y., Zhang, J., Shibuya, K., Shibuya, A., Bannai, M.,
Tokunaga, K., Doi, H., Tamari, M., Shimizu, M., Shirakawa, T., Shibasaki, M.,
Ichikawa, K. and Arinami, T.,
Am J Respir Crit Care Med, 172, 183-8, 2005.
Suppression of eosinophilic airway inflammation by treatment with
alpha-galactosylceramide.
Morishima, Y., Ishii, Y., Kimura, T., Shibuya, A., Shibuya, K., Hegab, A. E., Iizuka,
T., Kiwamoto, T., Matsuno, Y., Sakamoto, T., Nomura, A., Taniguchi, M. and
Sekizawa, K.,
Eur J Immunol, 35, 2803-2814, 2005.
"Fca/mR, a novel Fc receptor for innate antibodies IgM and IgA,"
Honda, S., Miyamoto, A. and Shibuya, A.,
Elsevier B.V., 2005.
Functional characterization of DNAM-1 (CD226) interaction with its
ligands PVR (CD155) and nectin-2 (PRR-2/CD112).
Tahara-Hanaoka, S., Shibuya, K., Onoda, Y., Zhang, H., Yamazaki, S., Miyamoto,
A., Honda, S. I., Lanier, L. L. and Shibuya, A.,
Int Immunol, 16, 533-538, 2004.
Successful gene transfer into human CD4 positive T cells mediated
by lentiviral vectors.
Shibuya, K., Miyoshi, H., Wang, Y., Kai, H. and Shibuya, A.,
Immunology, 2004 12, 91-94, 2004.
Treatment with alpha-galactosylceramide attenuates the
development of bleomycin-induced pulmonary fibrosis.
Kimura, T., Ishii, Y., Morishima, Y., Shibuya, A., Shibuya, K., Taniguchi, M.,
Mochizuki, M., Hegab, A. E., Sakamoto, T., Nomura, A. and Sekizawa, K.,
J Immunol, 172, 5782-9, 2004.
Paired activating and inhibitory immunoglobulin-like receptors,
MAIR-I and MAIR-II, regulate mast cell and macrophage activation.
Yotsumoto, K., Okoshi, Y., Shibuya, K., Yamazaki, S., Tahara-Hanaoka, S., Honda,
S., Osawa, M., Kuroiwa, A., Matsuda, Y., Tenen, D. G., Iwama, A., Nakauchi, H.
and Shibuya, A.,
J Exp Med, 198, 223-33, 2003.
Transgenic Overexpression of GATA-3 in T Lymphocytes Improves
Autoimmune Glomerulonephritis in Mice with a BXSB/MpJ-Yaa
Genetic Background.
Yoh, K., Shibuya, K., Morito, N., Nakano, T., Ishizaki, K., Shimohata, H., Nose, M.,
Izui, S., Shibuya, A., Koyama, A., Engel, J. D., Yamamoto, M. and Takahashi, S.,
J Am Soc Nephrol, 14, 2494-502, 2003
Development and functions of natural killer cells.
Shibuya, A.,
Int J Hematol, 78, 1-6, 2003.
CD226 (DNAM-1) is involved in lymphocyte function-associated
antigen 1 costimulatory signal for naive T cell differentiation and
proliferation.
Shibuya, K., Shirakawa, J., Kameyama, T., Honda, S., Tahara-Hanaoka, S.,
Miyamoto, A., Onodera, M., Sumida, T., Nakauchi, H., Miyoshi, H. and Shibuya, A.,
J Exp Med, 198, 1829-39, 2003.
Expression of Fc receptor for immunoglobulin M in oligodendrocytes
and myelin of mouse central nervous system.
Nakahara, J., Seiwa, C., Shibuya, A., Aiso, S. and Asou, H.,
Neurosci Lett, 337, 73-6, 2003.
CD226 mediates platelet and megakaryocytic cell adhesion to
vascular endothelial cells.
Kojima, H., Kanada, H., Shimizu, S., Kasama, E., Shibuya, K., Nakauchi, H.,
Nagasawa, T. and Shibuya, A.,
J Biol Chem, 278, 36748-53, 2003.
Successful multilineage engraftment of human cord blood cells in
pigs after in utero transplantation.
Fujiki, Y., Fukawa, K., Kameyama, K., Kudo, O., Onodera, M., Nakamura, Y.,
Yagami, K., Shiina, Y., Hamada, H., Shibuya, A. and Nakauchi, H.,
Transplantation, 75, 916-22, 2003.
"DNAM-1 is a leukocyte adhesion molecule associated with LFA-1.,"
Shibuya, A., Shibuya, K., Yotsumoto, K. and Nakauchi, H.,
Oxford University Press, 2002.
"CD226(DNAM-1,PTA1,Tlisa),"
Lanier, L. L., Shibuya, A. and Burns, G.,
Oxford University Press, 2002.
Reciprocal roles for CCAAT/enhancer binding protein (C/EBP)
and PU.1 transcription factors in Langerhans cell commitment.
Iwama, A., Osawa, M., Hirasawa, R., Uchiyama, N., Kaneko, S., Onodera, M.,
Shibuya, K., Shibuya, A., Vinson, C., Tenen, D. G. and Nakauchi, H.,
J Exp Med, 195, 547-58, 2002.
Killer T-cell induction in patients with blastic natural killer cell
lymphoma/leukaemia: implications for successful treatment and
possible therapeutic strategies.
Yamada, O., Ichikawa, M., Okamoto, T., Park, C., Motoji, T., Mizoguchi, H. and
Shibuya, A.,
Br J Haematol, 113, 153-60, 2001.
Molecular cloning and characterization of mouse Tspan-3, a novel
member of the tetraspanin superfamily, expressed on resting
dendritic cells.
Tokoro, Y., Shibuya, K., Osawa, M., Tahara-Hanaoka, S., Iwama, A., Kitamura, T.,
Nakauchi, H. and Shibuya, A.,
Biochem Biophys Res Commun, 288, 178-83, 2001.
Fc(alpha)/mu receptor is a single gene-family member closely
related to polymeric immunoglobulin receptor encoded on Chromosome 1.
Shimizu, Y., Honda, S., Yotsumoto, K., Tahara-Hanaoka, S., Eyre, H. J.,
Sutherland, G. R., Endo, Y., Shibuya, K., Koyama, A., Nakauchi, H. and Shibuya, A.,
Immunogenetics, 53, 709-11, 2001.
"Identification of Fc alpha/mu receptor expressed on
B lymphocytes and macrophages.,"
Shibuya, A., Shibuya, K., Shimizu, Y., Yotsumoto, K. and Nakauchi, H.,
Springer-Verlag Press, 2001.
A novel Fc receptor for IgA and IgM is expressed on both
hematopoietic and non-hematopoietic tissues.
Sakamoto, N., Shibuya, K., Shimizu, Y., Yotsumoto, K., Miyabayashi, T., Sakano,
S., Tsuji, T., Nakayama, E., Nakauchi, H. and Shibuya, A.
Eur J Immunol, 31, 1310-6, 2001.
Increased cell surface expression of C-terminal truncated
erythropoietin receptors in polycythemia.
Motohashi, T., Nakamura, Y., Osawa, M., Hiroyama, T., Iwama, A., Shibuya, A.
and Nakauchi, H.
Eur J Haematol, 67, 88-93, 2001.
Fc alpha/mu receptor mediates endocytosis of IgM-coated
microbes.
Shibuya, A., Sakamoto, N., Shimizu, Y., Shibuya, K., Osawa, M., Hiroyama, T.,
Eyre, H. J., Sutherland, G. R., Endo, Y., Fujita, T., Miyabayashi, T., Sakano, S.,
Tsuji, T., Nakayama, E., Phillips, J. H., Lanier, L. L. and Nakauchi, H?.
Nat Immunol, 1, 441-6, 2000.
Serological analysis of BALB/C methylcholanthrene sarcoma Meth
A by SEREX: identification of a cancer/testis antigen.
Ono, T., Sato, S., Kimura, N., Tanaka, M., Shibuya, A., Old, L. J. and Nakayama, E.
Int J Cancer, 88, 845-51, 2000.
Molecular cloning and chromosomal mapping of a novel five-span
transmembrane protein gene, M83.
Motohashi, T., Miyoshi, S., Osawa, M., Eyre, H. J., Sutherland, G. R., Matsuda, Y.,
Nakamura, Y., Shibuya, A., Iwama, A. and Nakauchi, H.
Biochem Biophys Res Commun, 276, 244-50, 2000.
Molecular cloning and characterization of CRLM-2, a novel type I
cytokine receptor preferentially expressed in hematopoietic cells.
Hiroyama, T., Iwama, A., Morita, Y., Nakamura, Y., Shibuya, A. and Nakauchi, H.
Biochem Biophys Res Commun, 272, 224-9, 2000.
Dominant expansion of human T cells in non-obese diabetic/severe
combined immunodeficiency mice implanted with human bone
fragments.
Fujiki, Y., Onodera, M., Yamaguchi, T., Osawa, M., Sudo, K., Hamada, H., Ema, H.,
Shibuya, A., Takiguchi, M., Kubo, T. and Nakauchi, H.,
Exp Hematol, 28, 792-801, 2000.
Physical and functional association of LFA-1 with DNAM-1
adhesion molecule.
Shibuya, K., Lanier, L. L., Phillips, J. H., Ochs, H. D., Shimizu, K., Nakayama, E.,
Nakauchi, H. and Shibuya, A.,
Immunity, 11, 615-23, 1999.
Comparison of hematopoietic activities of human bone marrow and
umbilical cord blood CD34 positive and negative cells.
Kim, D. K., Fujiki, Y., Fukushima, T., Ema, H., Shibuya, A. and Nakauchi, H.,
Stem Cells, 17, 286-94, 1999.
Effects of total and partial X-irradiation on hematopoiesis.
Fuji, H. S. and Shibuya, A.,
Cytometry Res, 9, 29-35, 1999.
Characterization of a novel human natural killer-cell line (NK-YS)
established from natural killer cell lymphoma/leukemia associated
with Epstein-Barr virus infection.
Tsuchiyama, J., Yoshino, T., Mori, M., Kondoh, E., Oka, T., Akagi, T., Hiraki, A.,
Nakayama, H., Shibuya, A., Ma, Y., Kawabata, T., Okada, S. and Harada, M.,
Blood, 92, 1374-83, 1998.
Variable expression on lung cancer cell lines of HLA-A2-binding
MAGE-3 peptide recognized by cytotoxic T lymphocytes.
Takaki, T., Hiraki, A., Uenaka, A., Gomi, S., Itoh, K., Udono, H., Shibuya, A., Tsuji,
T., Sekiguchi, S. and Nakayama, E.,
Int J Oncol, 12, 1103-9, 1998.
Protein kinase C is involved in the regulation of both signaling and
adhesion mediated by DNAX accessory molecule-1 receptor.
Shibuya, A., Lanier, L. L. and Phillips, J. H.,?
J Immunol, 161, 1671-6, 1998.
DNAM-1, a novel adhesion molecule involved in the cytolytic
function of T lymphocytes.
Shibuya, A., Campbell, D., Hannum, C., Yssel, H., Franz-Bacon, K., McClanahan,
T., Kitamura, T., Nicholl, J., Sutherland, G. R., Lanier, L. L. and Phillips, J. H.,
Immunity, 4, 573-81, 1996.
Applications of retrovirus-mediated expression cloning.
Onishi, M., Kinoshita, S., Morikawa, Y., Shibuya, A., Phillips, J., Lanier, L. L.,
Gorman, D. M., Nolan, G. P., Miyajima, A. and Kitamura, T.,
Exp Hematol, 24, 324-9, 1996.
Lymphokine requirement for the generation of natural killer cells
from CD34+ hematopoietic progenitor cells.
Shibuya, A., Nagayoshi, K., Nakamura, K. and Nakauchi, H.,
Blood, 85, 3538-46, 1995.
Efficient screening of retroviral cDNA expression libraries.
Kitamura, T., Onishi, M., Kinoshita, S., Shibuya, A., Miyajima, A. and Nolan, G. P.,
Proc Natl Acad Sci U S A, 92, 9146-50, 1995.
Enrichment of interleukin-2-responsive natural killer progenitors in
human bone marrow.
Shibuya, A., Kojima, H., Shibuya, K., Nagayoshi, K., Nagasawa, T. and Nakauchi, H.,
Blood, 81, 1819-26, 1993.
[Effect of THP-CVP regimen for elderly patients with malignant
lymphoma].
Mitsuhashi, S., Ninomiya, H., Shibuya, A., Kojima, H., Nagasawa, T., Ohsaka, A.,
Watanabe, T., Kawachi, S., Watanabe, N., Ishida, H. and et al.,
Rinsho Ketsueki, 34, 1532-9, 1993.
Successful treatment of a patient with adult T-cell leukemia by
daily oral administration of low-dose etoposide. Decrease in the
amount of HTLV-I proviral DNA revealed by the polymerase chain
reaction method.
Kojima, H., Hori, M., Shibuya, A., Nagasawa, T., Miwa, M. and Abe, T.,
Cancer, 72, 3614-7, 1993.
[Human parvovirus B19-induced aplastic crisis in an elderly man
with intestinal hemorrhage].
Kamoshita, M., Ohtani, K., Hasegawa, Y., Satoh, Y., Kozima, H., Shibuya, A.,
Ninomiya, H., Nagasawa, T., Matsunaga, Y. and Abe, T.,
Rinsho Ketsueki, 34, 493-5, 1993.
[Treatment of elderly patients with chronic idiopathic
thrombocytopenic purpura].
Hasegawa, Y., Nagasawa, T., Kojima, H., Shibuya, A., Ninomiya, H. and Abe, T.,
Rinsho Ketsueki, 34, 460-4, 1993.
Suppressive effect of granulocyte-macrophage colony-stimulating
factor on the generation of natural killer cells in vitro.
Taguchi, K., Shibuya, A., Inazawa, Y. and Ab?e, T.,
Blood, 79, 3227-32, 1992.
[Clinicopathological study of 6 cases of mantle zone lymphoma].
Shibuya, A., Muraki, Y., Satoh, Y., Kobayashi, T., Kojima, H., Nagasawa, T., Abe,
T., Tomiyama, J., Kudoh, H., Adachi, Y. and et al.,
Rinsho Ketsueki, 33, 770-5, 1992.
[Anorexia nervosa with neutropenia--response of neutrophils to
G-CSF].
Muraki, Y., Kobayashi, T., Kojima, H., Shibuya, A., Nagasawa, T., Abe, T.
and Mori, N.,
Rinsho Ketsueki, 33, 328-32, 1992.
Inhibitory effect of granulocyte-macrophage colony-stimulating
factor therapy on the generation of natural killer cells.
Shibuya, A., Taguchi, K., Kojima, H. and Abe, T.,
Blood, 78, 3241-7, 1991.
[Adult T cell lymphoma/leukemia with alopecia, huge tumors of
scalp and wide destruction of cerebral bone].
Natsuda, H., Muraki, Y., Kobayashi, T., Kozima, H., Shibuya, A., Nagasawa, T.
and Abe, T.,
Rinsho Ketsueki, 32, 537-41, 1991.
[Primary myelofibrosis with extramedullary haematopoiesis of the
skin transformed into acute megakaryoblastic leukemia].
Sato, Y., Shibuya, A., Kudo, H., Adachi, Y., Kinugasa, K., Matsumoto, M.
and Aoki, M.,
Rinsho Ketsueki, 31, 204-8, 1990.
Terminal differentiation to mature neutrophils and eosinophils in
suspension culture of the blast progenitors in acute myeloblastic
leukemia.
Nara, N., Tohda, S., Suzuki,T., Nagata, K., Yamashita,Y., Imai, Y., Morio, T.,
Bessho, M., Shibuya, A., Adachi, Y.,
Hematol Pathol, 4, 125-34, 1990
A double Philadelphia chromosome in myelodysplastic syndrome.
Shibuya, A., Tomiyama, J., Nakazawa, M., Abe, T. and Kondo, I.,
Nippon Ketsueki Gakkai Zasshi, 52, 707-11, 1989.
[A case report of intrapericardial malignant pheochromocytoma].
Iwama, T., Satou, N., Satou, Y., Shibuya, A., Adachi, Y. and Suzuki, F.,
Nippon Naika Gakkai Zasshi, 78, 1484-5, 1989.
Characterization of natural killer cells cultured from human bone
marrow cells.
Yoda, Y., Kawakami, Z., Shibuya, A. and Abe, T.,
Exp Hematol, 16, 712-7, 1988.
[Transformation of ALL to acute mixed leukemia].
Tomiyama, J., Sato, Y., Kobayashi, T., Shibuya, A., Ninomiya, H., Nagasawa, T.,
Yoda, Y. and Abe, T.,
Rinsho Ketsueki, 29, 2121-6, 1988.
Oxymetholone therapy in patients with familial antithrombin III
deficiency.
Shibuya, A., Ninomiya, H., Nakazawa, M., Nagasawa, T., Yoda, Y. and Abe, T.,
Thromb Haemost, 60, 495-7, 1988.
[Acute mixed leukemia (AMixL) with both myeloid and lymphoid
phenotypes: selection of treatment for AMixL].
Ohse, H., Nagasawa, T., Ninomiya, H., Shibuya, A., Nakazawa, M., Yoda, Y.
and Abe, T.,
Rinsho Ketsueki, 29, 577-83, 1988.
[Recurrence of thromboses and infections in a patient with
paroxysmal nocturnal hemoglobinuria (PNH)].
Ninomiya, H., Tomiyama, J., Imagawa, S., Shibuya, A., Hanada, T., Kageoka, T.,
Nagasawa, T., Yoda, Y., Abe, T. and Fujita, T.,
Rinsho Ketsueki, 29, 54-8, 1988.
[Inhibitory activity of T cells on hematopoiesis and gamma-IFN
production by T cells from peripheral blood in patients with
aplastic anemia].
Hanada, T., Yamamura, H., Ehara, T., Nakahara, S., Shibuya, A., Abe, T.
and Takita, H.,
Nippon Ketsueki Gakkai Zasshi, 51, 571-5, 1988.
[A study on the hematopoietic recovery in patients with aplastic
anemia successfully treated with immunosuppressive therapy].
Hanada, T., Yamamura, H., Ehara, T., Nakahara, S., Shibuya, A., Abe, T.
and Takita, H.,
Rinsho Ketsueki, 29, 14-8, 1988.
[A study of the incidence of ATL (adult T-cell leukemia) and
anti-ATLA (antibody to the ATL-associated antigen) in an
ATL-non-endemic area].
Shibuya, A., Ninomiya, H., Nakazawa, M.?, Kageoka, T. and Yoda, Y.,
Rinsho Ketsueki, 28, 852-6, 1987.
[Congenital antithrombin III (ATIII) deficiency with thrombosis of
superior sagittal sinus and of inferior vena cava].
Shibuya, A., Ninomiya, H., Nakazawa, M., Nagasawa, T., Yoda, Y. and Abe, T.,
Rinsho Ketsueki, 28, 2000-3, 1987.
Immunological erythroblastopenia induced by HCO-60 as a solvent
of enocitabine (BH-AC).
Ninomiya, H., Hanada, T., Nakazawa, M., Aoki, Y., Shibuya, A., Nagasawa, T.
and Abe, T.,
Nippon Ketsueki Gakkai Zasshi, 50, 777-83, 1987.
[A case of pure red cell aplasia with monoclonal gammopathy:
immune-mediated inhibition of erythropoiesis].
Kobayashi, T., Hanada, T., Sato, Y., Shibuya, A., Ninomiya, H., Nagasawa, T.
and Abe, T.,
Rinsho Ketsueki, 28, 2029-33, 1987.
[Cerebellar infarction following remission induction therapy in
acute lymphoblastic leukemia].
Aoki, Y., Shibuya, A., Ninomiya, H., Nakazawa, M., Nakamura, H., Kageoka, T.,
Nagasawa, T., Yoda, Y. and Abe, T.,
Rinsho Ketsueki, 28, 624-8, 1987.
[Mitral regurgitation due to ruptured chordae tendineae:
sensitivity and specificity of the diagnostic criteria by
two-dimensional echocardiography].
Takenaga, M., Ohno, M., ?Shibuya, A., Hara, K., Tsuneyoshi, H., Takeuchi, H.,
Kashida, M., Yamaguchi, T., Machii, K. and Furuta, S.,
J Cardiogr, 16, 105-13, 1986.
Transmission of HTLV-1 by blood transfusion in an
ATL-non-endemic area.
Shibuya, A., Kageoka, T., Ninomiya, H., Aoki, Y., Nakazawa, M., Hanada, T.
and Abe, T.,
Nippon Ketsueki Gakkai Zasshi, 49, 1206-11, 1986.
[Abnormal expansion of azurophilic granular lymphocytes with
peculiar surface phenotype in a case of malignant lymphoma].
Ninomiya, H., Yoda, Y., Shibuya, A., Nakazawa, M., Nagasawa, T., Abe, T.,
Mori, N. and Komiyama, A.,
Rinsho Ketsueki, 27, 2168-72, 1986.
Successful treatment of acute megakaryoblastic leukaemia.
Ninomiya, H., Nakazawa, M., Shibuya, A., Aoki, Y., Nagasawa, T. and Abe, T.,
Scand J Haematol, 36, 147-53, 1986.
Diffuse hepatic calcification as a sequela to shock liver.
Shibuya, A., Unuma, T., Sugimoto, T., Yamakado, M., Tagawa, H., Tagawa, K.,
Tanaka, S. and Takanashi, R.,
Gastroenterology, 89, 196-201, 1985.
[A family of congenital factor XI deficiency].
Shibuya, A., Saitoh, K. and Fujioka, S.,
Rinsho Ketsueki, 26, 1516-9, 1985.
[A case of chronic renal failure with diffuse hepatic and
myocardial calcification].
Shibuya, A., Sugimoto, T., Yamakado, M., Tagawa, H., Unuma, T., Yamaguchi, T.,
Machii, K. and Tanaka, S.,
Nippon Naika Gakkai Zasshi, 74, 1257-64, 1985.
Cellular characteristics of neoplastic angioendotheliosis.
An immunohistological marker study of 6 cases.
Mori, S., Itoyama, S., Mohri, N., Shibuya, A., Hirose, T., Takanashi, R., Oshimi, K.,
Mizoguchi, H. and Epstein, A. E.,
Virchows Arch A Pathol Anat Histopathol, 407, 167-75, 1985.
A case of Malignant angioendotheliomatosis
Shibuya, A., Saitoh, K., Tanaka, S. and Takanashi, R.,
Jpn J Ret Sys, 23, 197-201, 1983.
Burkitt's lymphoma in a haemophili.
Shibuya, A., Saitoh, K., Tsuneyoshi, H. and Tanaka, S.,
Lancet, 2, 1432, 1983.