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【講師】 Dr. Kiyoshi Takeda

【所属】 Professor 
             Department of Microbiology and Immunology,
             Graduate School of Medicine and IFReC
             Program Coordinator of Interdisciplinary
             Program for Biomedical Sciences,
             Leading graduate School, Osaka University

【日時】 平成30年9月19日(水)午後17:00-18:30

【場所】 医学医療系棟4階483号室

Intestine is a unique tissue where several environmental factors including commensal bacteria
and dietary components exist. In a healthy condition, activity of intestinal immunity is finely
regulated to prevent inflammatory responses to these environmental factors. Dysregulated
interaction of intestinal environmental factors and intestinal immunity causes development of
inflammatory bowel disease (IBD) represented by Crohn’s disease and ulcerative colitis.
We are analyzing the mechanisms by which gut homeostasis is regulated by focusing on barrier
function of colonic epithelial cells that are responsible for segregation of intestinal bacteria and
immunity. Indeed, the presence of bacteria on the epithelial surface of the large intestine was
reported in several mouse models of intestinal inflammation. We found that Lypd8, which is
selectively expressed on colonic epithelial cells, blocks direct interaction of intestinal bacteria with
the host cells.
We are also analyzing how intestinal bacteria, which do not directly contact the intestinal epithelia,
act on the host. In this regard, we recently identified bacterial metabolites that initiate immune
responses by acting of intestinal myeloid cells. We will also discuss the bacterial metabolites. 

This seminar will be held in English


問合せ先: 医学医療系・免疫学
渋谷 彰(ashibuya@md.tsukuba.ac.jp