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【演題】 IL-33 amplifies the expansion of natural killer cells and enhances host defense during mouse cytomegalovirus infection

【講師】 Tsukasa Nabekura, Ph.D.

【所属】 Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, U.S.A. /Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, Japan

【日時】 平成27年7月14日(火)17:00-18:15
【場所】 Seminar room, Building A, TARA Center
【講演要旨】  Natural killer (NK) cells provide important host defense against viruses and can differentiate into self-renewing memory NK cells after infection, alloantigen stimulation, and cytokine stimulation.  In this study, we investigated the role of the interleukin (IL)-33 receptor ST2 in the differentiation of NK cells during mouse cytomegalovirus (MCMV) infection.  Although ST2-deficient (Il1rl1−/−) Ly49H+ NK cells develop normally and differentiate into memory cells after MCMV infection, naïve and memory Il1rl1−/− Ly49H+ NK cells exhibited profound defects in MCMV-specific expansion, resulting in impaired protection against MCMV challenge.  Additionally, IL-33 enhanced MCMV m157 antigen-specific proliferation of Ly49H+ NK cells in the presence of IL-12 in vitro.  Thus, an IL-33-ST2 signaling axis in NK cells contributes to host defense against MCMV.

This seminar will be held in English

詳細はこちらをご覧下さい。 seminar63.pdf

問合せ先: 医学医療系・免疫学
渋谷 彰(ashibuya@md.tsukuba.ac.jp